August 30, 2010

BrainFuals.com’s articles on brain aging, neuroprotectors, and more

The last five articles by the Brain Fuels (click on titles to read)

  • The MMM of aging: mood, memory, movement
  • The seven effects of ketone bodies making them powerful neuroprotectors
  • Books by Alexander Luria in English
  • A serious reason to avoid energy drinks: they can cause seizures
  • Comparison of lactate kinetics in vitro and in vivo is to be done
  • August 2, 2010

    Carbohydrate Addict Diet – an intermittent ketosis plan?

    Intermittent fasting is popular today. One of the aspects of this calorie restriction techniques is periodic ketosis, which is proved to be  neuroprotective. Another aspect is periodic interruption of glycolysis, which is also good for the brain. However, the Hellers were first to empirically formulate the idea and make it very dieter-friendly: Rachael F. Heller, Richard F. Heller. The Carbohydrate Addict’s Diet: The Lifelong Solution to Yo-Yo Dieting. Signet (1993)

    intermittent ketosis<– Carbohydrate Addict Diet Food Pyramid

    This diet is for you if you have:

    • forceful hunger
    • craving for carbohydrate-rich foods
    • need for starches
    • desire for snack foods, junk food, or sweets?

    Do you have problems:

    • staying away from food between meals
    • staying away from snacks at night
    • stopping a meal containing starches and sweets
    • eating tasty food while not being hungry
    • staying alert after a large meal
    • staying alert early afternoon
    • keeping your weight off after losing weight due to dieting

    Do you tend to overeat these foods:

    • Breads
    • Bagels
    • Cakes
    • Cereal
    • Chocolate
    • Cookies
    • Crackers
    • fruit
    • juice
    • ice cream
    • potatoes
    • pasta
    • rice
    • popcorn
    • sodas?

    Do you indulge in:

    • sugar substitutes
    • alcohol
    • monosodium glutamate?

    If you answered “yes” to at least one of the questions in each category, the CAD might be right for you.

    The diet prescribes two meals, called Complementary Meals, which limit carbohydrate generally same way most low carb diets do. Most people choose breakfast and lunch for their complementary meals. The diet allows one Reward Meal not limiting carbohydrate content but limiting this meal’s duration to strictly one hour. It is believed that with this meal planning you body is tricked into releasing less insulin. Thus, it better controls blood sugar levels and therefore stores less fat.

    The diet starts with the Entry Plan. You eat two complementary meals and a reward meal, no snacks, for a week, then you weigh. Your plan for the next week will depend on your weight loss and your weight loss goal. For instance, if you loss was around 2 pounds, you go to the Plan A, which is essentially same plan, but you are allowed to have a low carb snack.

    If after following the Entry Plan for a week you lost 0.5 lb. To 2 lb., you go to the Plan B, which is in fact staying on the Entry Plan for one more week.

    If you didn’t lose any weight on Entry Plan, you go to the Plan C and this is an interesting part. All you do differently comparing with the Entry Plan, is eating two big salads made of leafy green vegetables before both of your two daily complementary meals.

    There’s also the Plan D, for the most stubborn body weight, where you add one more salad, before your Reward Meal. This planning goes on every new week.

    From the book:

    The Banta Diet: A diet mobilizing the fat burning biochemical pathway. 92 % success rate since 2002

    Reprinted with permission

    May 6, 2010

    Wrong foods for ADHD

    The ‘few foods’ elimination diet (Arch Dis Child, 2001 84:404–409) is considered “a valuable instrument” for both testing the foods to blame for ADHD and, after eliminating these foods, for improving children’s behavior. 69.4% reduction on the ADHD assessment scale comparing with 45.3% in control group without dietary intervention (Eur Child & Adolescent Psychiatry, Volume 18, Number 1 / January, 2009).

    The method

    There are so called oligo-antigenic foods — foods that are unlikely to produce an adverse behavioral response: lamb, chicken, potatoes, rice, banana, apple and brassica (e.g., broccoli, Brussels sprouts, cabbage, Chinese cabbage, cauliflower, kale, kohlrabi, etc).

    Additional foods were reintroduced, one by one, and if there was no adverse reaction they were retained in the diet. Foods causing adverse reactions were tested in a double-blind control setting: out of two similar meals only one contained the food causing an adverse reaction another being an analog of different chemical nature, for example, cows milk versus soya milk.

    The usual suspects

    Cows milk caused an adverse reaction in 64% of children; chocolate (59%), grapes (49%), wheat (49%), oranges (45%), cows cheese (40%) and hens egg (39%).

    Food intolerance and behavior

    • Some children with ADHD respond adversely to certain foods.
    • Among the more common foods to blame are wheat, dairy products and chocolate.
    • Not all children sharing diagnosis such as ADHD responded similarly to the diet intervention.

    April 17, 2010

    The gut-brain-skin axis and probiotics

    There are quite a few axes where the brain is involved. The most studied is hypothalamic–pituitary–adrenal axis dealing mostly with stress and the sleep/wake cycle and the hypothalamic-pituitary-gonadal axis reproduction, life cycle, and sexual dimorphism & behavior. Recently, emerging evidence supports the existence of communication axes between other organs as well, with the central role of the brain remaining. The gut-brain-skin axis is thought to be responsible also for the stress challenge that, if not managed, can cause skin inflammation and the hair growth inhibition. The good news is, there are ways to deal with the challenge by improving of the microflora of the guts by probiotics (Exp Dermatol. 2010 Jan 25).
    For example, myocardial infarction (heart attack) causes the release of pro-inflammatory substances that may affect the function of other organs including various structures brain where they result in an increase in cell death (J Psychopharmacol 2009, 23, 451–459; Biol Psychiatry 2006, 59, 430–433) while the friendly probiotic bacteria Lactobacillus helveticus and Bifidobacterium longum taken in combination reduced these adverse effects (British Journal of Nutrition (2009), 102:1420-1425).
    A spectacular result proving the gut-brain axis influence on the quality of life has been presented in the European Journal of Clinical Nutrition (2007, 61, 355–361). Those participants of the double blind controlled trial who reported themselves to be constipated infrequently were more clearheaded, confident and elated. When the participants prone to be depressed at the onset of the trial where treated with probiotics, they responded by reporting themselves as happy rather than depressed while these changes were not observed in the control group taking milk drinks containing no probiotics.

    There are quite a few so called “axes” where the brain is involved. The most studied is hypothalamic–pituitary–adrenal axis dealing mostly with stress and the sleep/wake cycle and the hypothalamic-pituitary-gonadal axis reproduction, life cycle, and sexual dimorphism & behavior. Recently, emerging evidence supports the existence of communication axes between other organs as well, with the central role of the brain remaining. The gut-brain-skin axis is thought to be responsible also for the stress challenge that, if not managed, can cause skin inflammation and the hair growth inhibition. The good news is, there are ways to deal with the challenge by improving of the microflora of the guts by probiotics (Exp Dermatol. 2010 Jan 25).

    For example, myocardial infarction (heart attack) causes the release of pro-inflammatory substances that may affect the function of other organs including various structures brain where they result in an increase in cell death (J Psychopharmacol 2009, 23, 451–459; Biol Psychiatry 2006, 59, 430–433) while the friendly probiotic bacteria Lactobacillus helveticus and Bifidobacterium longum taken in combination reduced these adverse effects (British Journal of Nutrition (2009), 102:1420-1425).

    A spectacular result proving the gut-brain axis influence on the quality of life has been presented in the European Journal of Clinical Nutrition (2007, 61, 355–361). Those participants of the double blind controlled trial who reported themselves to be constipated infrequently were more clearheaded, confident and elated. When the participants prone to be depressed at the onset of the trial where treated with probiotics, they responded by reporting themselves as happy rather than depressed while these changes were not observed in the control group taking milk drinks containing no probiotics.

    April 7, 2010

    Coffee, tea, and chocolate can help to avoid Parkinson’s disease

    Parkinson’s disease, though having some genetic forms, is thought to be largely life style-related and since no treatments exist to prevent or slow the disease down, environmental factors are of great interest to scientists.  Earlier, in Germany (1) and Sweden, (2) consumption of coffee or caffeine have been shown to lower risk of Parkinson’s disease. However, there were some problems with interpretation of the results: coffee drinking was positively associated with  smoking and alcohol consumption (3).

    The Harvard School of Public Health followed up 183267 healthy people (free of Parkinson’s disease, cancer or stroke) during 10 years, watching their caffein intake with coffee, tee, chocolate and adjusting the results for age since and smocking since these two were strong risk factors in themselves (3). 288 cases of Parkinson’s disease were registered during this time. Women were more active coffee drinkers: the lower quintiles of caffein intake (taken as the reference point) in their population was  7 times higher than in men’s population.

    Every other quintile in men had a lower risk of Parkinson’s disease, however, in women, the highest quintile was not associated with risk decrease – women consuming the largest amounts of caffein have had the same risk as those consuming the least caffein and for some of them the risk increased up to 1.8 times. The average highest caffein intake was 1.3 times higher in women than in men but the authors hesitate contributing the U-shaped of intake/risk curve to this difference and argued that “plausible biological basis for a protective effect of caffeine” should be established before making conclusions.

    Read also:

    Caffeine protect against neurodegeneration in Alzheimer’s disease

    Sources

    1. Hellenbrand W, Seidler A, Robra B-P, et al. Smoking and Parkinson’s disease: a case control study in Germany. Int J Epidemiol 1997; 26: 328-339. Links
    2. Fall P-A, Frederikson M, Axelson O, Granérus A-K. Nutritional and occupational factors influencing the risk of Parkinson’s disease: a case-control study in southeastern Sweden. Mov Disord 1999; 14: 28-37. Links
    3. Ascherio A, Zhang SM, Hernán MA, Kawachi I, Colditz GA, Speizer FE, Willett WCProspective study of caffeine consumption and risk of Parkinson’s disease in men and women. Ann Neurol. 2001 Jul;50(1):56-63.

    March 16, 2010

    Mood Effects of Low-carb Diets

    Among those shared with me their weight loss results while on Atkins diet, 347 dieters reported effects beyond weight loss (or its absence):

    • Hunger disappearance or appetite decrease – 178
    • Diabetes improvement – 169
    • Mood improvement, energy level increase – 158
    • Absence of cravings – 149
    • Physicians approval for the diet – 129
    • Joint and muscle improvement – 125
    • Headache disappearance – 121
    • Exercise improvement – 115
    • Muscle gain decrease – 112
    • Fungal/yeast infection disappearance – 111
    • Heartburn, bloating disappearance – 110
    • Thyroid condition improvement – 119

    Reported negative results:

    • Cravings for high-carb foods increase – 16
    • Inability to exercise – 15
    • Low-carb foods dissatisfaction – 14

    Mood/energy

    This particular effect is perhaps the most controversial because it is against the observations, including those conducted in controlled clinical settings, that carbohydrate-rich meals improve mood and energy levels. Apparently, the positive influence reported by the dieters, were due to Atkins diet long-term effects, because during first several days on the diet there were effects consistent with clinical observations on short-term effects of direct intra-gastric infusions of nutrients:

    “Hedonic tone was greater and tension lower after the saline and sucrose infusions than after the lipid infusion. From 3 to 3.5 h after ingestion, subjects felt significantly more sleepy after the lipid infusion than they did at these times after the saline infusion, and significantly more dreamy after the lipid infusion than they did after the sucrose infusion. (Physiology & Behavior. 63(4):621-8, 1998)

    Another article reporting the influence of nutrients on mood, stress that there were acute and not long term effects:

    “Mood improved (a decline in fatigue/dysphoria) following the low-fat/high carb breakfast compared to medium-fat/ medium-carbohydrate or high-fat/low-carbohydrate meals.” (”Acute effects on mood and cognitive performance of breakfasts differing in fat and carbohydrate content. “Appetite. 27(2):151-64, 1996)

    The short-term positive effects of high-carb meals can be used, for example, for alleviating the PMS syndrome:

    “The experimental carbohydrate intervention significantly decreased self-reported depression, anger, confusion, and carbohydrate craving 90-180 minutes after intake. Memory word recognition was also improved significantly.” (Obstetrics & Gynecology. 86(4 Pt 1):520-8, 1995)

    It is interesting that not all of the clinical studies came to the above conclusion. Study conducted by University of Sheffield, demonstrated that meals, particularly when rich in fat, significantly reduced pain perception in healthy human subjects.( Physiology & Behavior. 65(4-5):643-8, 1999)

    Carbohydrate craving obese patients do not improve their mood states through ingestion of a carbohydrate-rich snack. (International Journal of Obesity & Related Metabolic Disorders. 21(10):860-4, 1997)

    There were no differences in mood between the groups receiving high-carb drink or water during performance of the military tasks. (Aviation Space & Environmental Medicine. 68(5):384-91, 1997)

    The ingestion of sucrose failed to have any substantial effect on mood (Physiology & Behavior. 58(3):421-7, 1995)

    “The carbohydrate-supplemented group had a greater total energy intake and carbohydrate intake. No significant differences between carbohydrate were observed in remaining psychological, physiological, or performance-related variables.” (International Journal of Sport Nutrition. 5(2):125-35, 1995)

    These are rather typical messages:

    • I feel great and my energy level has increased. I don’t feel sluggish anymore.
    • No more mood swings, brain fog, confusion, or depression.
    • I feel healthier, more energy (can keep up with the kids, yeah!) and smarter.
    • I have a much higher energy level as well as a much more pleasant disposition.
    • I have lots of energy and a lot more self esteem.
    • I am sleeping like a teenager, and I had sleep apnea before starting the diet.
    • I sleep better and I have more energy than my 16 year old daughter
    • I’m so infused with energy that I climb the stairs at work without huffing and puffing.
    • My energy had increased! Muscle tone had improved even though I wasn’t going to the gym.
    • When I am eating according to program I feel so much better, sleep better and have more energy
    • After the first 3 days the increase in energy was unbelievable, the mental fog and Monday morning blues were gone.
    • I have more energy, not so tired anymore, and feel like I’m in control of my appetite.
    • I have had a sense of inner peace that I simply can’t explain.
    • My mood swings have lifted and I’m a much happier person overall.
    • I felt better, had more energy, no more brain-fog and I did not feel tired and worn out at the end of the day.

    Most fats seem to be protective against Alzheimer’s disease

    Most fats seem to be protective against Alzheimer disease
    In 1989-99, an association was found, between dietary fat composition and cognitive performance in later adult years: the higher intake of monounsaturated and polyunsaturated fats and the lower intake of saturated fat — the higher cognitive performance. Another, epidemiologic study conducted in 1997 suggested that high intake of total fat, saturated fat, and dietary cholesterol may increase the risk of dementia.
    However, researchers at St Luke’s Medical Center, Chicago, Ill found increased risk of Alzheimer’s disease among people with high intakes of saturated and trans-unsaturated fats and decreased risk with high intakes of polyunsaturated and monounsaturated fats. Consumption of vegetable fat and a high ratio of polyunsaturated to saturated fats were also protective, whereas total fat, animal fat, and dietary cholesterol had no association with Alzheimer disease.
    Sources
    Brain Res. 1989;505:302-305
    Behav Neurosci. 1996;110:451-459
    Behav Brain Res. 1999;101:153-161
    Am J Epidemiol. 1997;145:33-41.
    Arch Neurol. 2003;60:194-200

    In 1989-99, an association was found, between dietary fat composition and cognitive performance in later adult years: the higher intake of monounsaturated and polyunsaturated fats and the lower intake of saturated fat — the higher cognitive performance. Another, epidemiologic study conducted in 1997 suggested that high intake of total fat, saturated fat, and dietary cholesterol may increase the risk of dementia.

    However, researchers at St Luke’s Medical Center, Chicago, Ill found increased risk of Alzheimer’s disease among people with high intakes of saturated and trans-unsaturated fats and decreased risk with high intakes of polyunsaturated and monounsaturated fats. Consumption of vegetable fat and a high ratio of polyunsaturated to saturated fats were also protective, whereas total fat, animal fat, and dietary cholesterol had no association with Alzheimer disease.

    Sources

    1. Brain Res. 1989;505:302-305
    2. Behav Neurosci. 1996;110:451-459
    3. Behav Brain Res. 1999;101:153-161
    4. Am J Epidemiol. 1997;145:33-41.
    5. Arch Neurol. 2003;60:194-200




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