July 29, 2010

Foods that heal, foods that harm

Foods for the brain and mind (resources)





May 6, 2010

Wrong foods for ADHD

The ‘few foods’ elimination diet (Arch Dis Child, 2001 84:404–409) is considered “a valuable instrument” for both testing the foods to blame for ADHD and, after eliminating these foods, for improving children’s behavior. 69.4% reduction on the ADHD assessment scale comparing with 45.3% in control group without dietary intervention (Eur Child & Adolescent Psychiatry, Volume 18, Number 1 / January, 2009).

The method

There are so called oligo-antigenic foods — foods that are unlikely to produce an adverse behavioral response: lamb, chicken, potatoes, rice, banana, apple and brassica (e.g., broccoli, Brussels sprouts, cabbage, Chinese cabbage, cauliflower, kale, kohlrabi, etc).

Additional foods were reintroduced, one by one, and if there was no adverse reaction they were retained in the diet. Foods causing adverse reactions were tested in a double-blind control setting: out of two similar meals only one contained the food causing an adverse reaction another being an analog of different chemical nature, for example, cows milk versus soya milk.

The usual suspects

Cows milk caused an adverse reaction in 64% of children; chocolate (59%), grapes (49%), wheat (49%), oranges (45%), cows cheese (40%) and hens egg (39%).

Food intolerance and behavior

• Some children with ADHD respond adversely to certain foods.
• Among the more common foods to blame are wheat, dairy products and chocolate.
• Not all children sharing diagnosis such as ADHD responded similarly to the diet intervention.

April 29, 2010

Caffeine protect against neurodegeneration in Alzheimer’s disease

Caffeine, the most widely consumed behaviourally active substance in the western world (Pharmacol Rev 51 1999: 83–133), has neuroprotective effects in cases of hypoxia and ischaemia (Brain Res Rev 33 2000: 258–274). Does caffeine protect against neurodegeneration in Alzheimer’s disease as it does in Parkinson’s? Researchers from Faculty of Medicine of Lisbon, Portugal, tested the hypothesis that average daily caffeine intake in the period of 20 years before the diagnosis could be lower than caffeine intake in age- and sex-matched healthy people and showed that indeed, people who was diagnosed with Alzheimer’s consumed an average 74 mg (less than one cup) while the controls had about 200 mg.
“These results, if confirmed with future prospective studies, may have a major impact on the prevention of AD,” concluded the researchers (Eur J Neurology, Volume 9, Issue 4, 2002: 377–382).
In a Canadian study, daily coffee intake decreased the risk of Alzheimer’s by 31% during a 5-year followup in 65-year old people [Am J Epidemiol 2002, 156, 445-453.]. The Finland, Italy and the
Netherlands Elderly (FINE) Study showed that elderly men drinking three cups of coffee daily had the least cognitive decline [Eur J Clin Nutr 2007, 61, 226-232]. Tea drinking  (Am J Epidemiol, 2004, 159, 959-967.], or flavonoid intake from tea  has not been associated with a reduced risk of dementia.
The low coffee consumers in mid-life had the highest occurrence of dementia and Alzheimer’s at late-life, and the highest scores on the depression scale (J Alzheimer’s Disease 16: 2009, 85–91).

Caffeine, the most widely consumed behaviourally active substance in the western world (Pharmacol Rev 51 1999: 83–133), has neuroprotective effects in cases of hypoxia and ischaemia (Brain Res Rev 33 2000: 258–274). Does caffeine protect against neurodegeneration in Alzheimer’s disease as it does in Parkinson’s? Researchers from Faculty of Medicine of Lisbon, Portugal, tested the hypothesis that average daily caffeine intake in the period of 20 years before the diagnosis could be lower than caffeine intake in age- and sex-matched healthy people and showed that indeed, people who was diagnosed with Alzheimer’s consumed an average 74 mg (less than one cup) while the controls had about 200 mg. ”These results, if confirmed with future prospective studies, may have a major impact on the prevention of Alzheimer’s,” concluded the researchers (Eur J Neurology, V 9, Issue 4, 2002: 377–382).

In a Canadian study, daily coffee intake decreased the risk of Alzheimer’s by 31% during a 5-year followup in 65-year old people (Am J Epidemiol 2002, 156, 445-453.). The Finland, Italy and the Netherlands Elderly (FINE) Study showed that elderly men drinking three cups of coffee daily had the least cognitive decline (Eur J Clin Nutr 2007, 61, 226-232). Tea drinking  (Am J Epidemiol, 2004, 159, 959-967.), or flavonoid intake from tea  has not been associated with a reduced risk of dementia. The low coffee consumers in mid-life had the highest occurrence of dementia and Alzheimer’s at late-life, and the highest scores on the depression scale (J Alzheimer’s Disease 16: 2009, 85–91).

One possible mechanism could involve insulin and degrading enzyme that degrades both insulin and amyloid-beta, the most suspected cause of Alzheimer’s (CNS Drugs 17, 2009, 27-45). Another mechanism is via adenosine receptors (caffein mimics effects of adenosine). It has been shown in mice that both caffeine and adenosine prevent amyloid-beta induced cognitive decline (Exp Neurol 203, 2007, 241-245).

April 17, 2010

The gut-brain-skin axis and probiotics

There are quite a few axes where the brain is involved. The most studied is hypothalamic–pituitary–adrenal axis dealing mostly with stress and the sleep/wake cycle and the hypothalamic-pituitary-gonadal axis reproduction, life cycle, and sexual dimorphism & behavior. Recently, emerging evidence supports the existence of communication axes between other organs as well, with the central role of the brain remaining. The gut-brain-skin axis is thought to be responsible also for the stress challenge that, if not managed, can cause skin inflammation and the hair growth inhibition. The good news is, there are ways to deal with the challenge by improving of the microflora of the guts by probiotics (Exp Dermatol. 2010 Jan 25).
For example, myocardial infarction (heart attack) causes the release of pro-inflammatory substances that may affect the function of other organs including various structures brain where they result in an increase in cell death (J Psychopharmacol 2009, 23, 451–459; Biol Psychiatry 2006, 59, 430–433) while the friendly probiotic bacteria Lactobacillus helveticus and Bifidobacterium longum taken in combination reduced these adverse effects (British Journal of Nutrition (2009), 102:1420-1425).
A spectacular result proving the gut-brain axis influence on the quality of life has been presented in the European Journal of Clinical Nutrition (2007, 61, 355–361). Those participants of the double blind controlled trial who reported themselves to be constipated infrequently were more clearheaded, confident and elated. When the participants prone to be depressed at the onset of the trial where treated with probiotics, they responded by reporting themselves as happy rather than depressed while these changes were not observed in the control group taking milk drinks containing no probiotics.

There are quite a few so called “axes” where the brain is involved. The most studied is hypothalamic–pituitary–adrenal axis dealing mostly with stress and the sleep/wake cycle and the hypothalamic-pituitary-gonadal axis reproduction, life cycle, and sexual dimorphism & behavior. Recently, emerging evidence supports the existence of communication axes between other organs as well, with the central role of the brain remaining. The gut-brain-skin axis is thought to be responsible also for the stress challenge that, if not managed, can cause skin inflammation and the hair growth inhibition. The good news is, there are ways to deal with the challenge by improving of the microflora of the guts by probiotics (Exp Dermatol. 2010 Jan 25).

For example, myocardial infarction (heart attack) causes the release of pro-inflammatory substances that may affect the function of other organs including various structures brain where they result in an increase in cell death (J Psychopharmacol 2009, 23, 451–459; Biol Psychiatry 2006, 59, 430–433) while the friendly probiotic bacteria Lactobacillus helveticus and Bifidobacterium longum taken in combination reduced these adverse effects (British Journal of Nutrition (2009), 102:1420-1425).

A spectacular result proving the gut-brain axis influence on the quality of life has been presented in the European Journal of Clinical Nutrition (2007, 61, 355–361). Those participants of the double blind controlled trial who reported themselves to be constipated infrequently were more clearheaded, confident and elated. When the participants prone to be depressed at the onset of the trial where treated with probiotics, they responded by reporting themselves as happy rather than depressed while these changes were not observed in the control group taking milk drinks containing no probiotics.

March 16, 2010

Nature’s antioxidants

Studies have shown that a diet rich in antioxidants, which are primarily provided by fruits and vegetables, may help prevent a variety of serious diseases Among the best known antioxidants are vitamins C and E, beta-carotene, selenium, ubiquinone (Q10) and the flavonoids found in wine, apples, onions and tea.

Surprisingly, cooked artichokes were found the highest-ranking vegetable-antioxidant. Even more of surprise was the discovery of antioxidative properties of potato placed on the top twenty list. (Health Evidence Network, WHO)

Comparing 40 fruit and beriries for their antioxidative activities researchers put wild blueberries to # 1 position. Among many health benefits listed were: memory and heart support, vision protection, urinary tract health, and cancer prevention. Cultivated blueberries were rated lower than their wild relatives (Journal of Agricultural and Food Chemistry, 52: 4026-4037, 2004)

Not only wild blueberries, but other berries such as: dog rose, sour cherry, blackberry, strawberry, raspberry, crowberry, and especially black currant are now considered potent antioxidants. Cranberries ranked sixth, with blackberries eighth, raspberries tenth, and strawberries eleventh. (August 1, 2004 — Vegparadise News Bureau)

The long-lasting champion championship of blueberries as antioxidants, recently a new candidate for the position has been announced – small red kidney beans, leaving blueberries slightly behind and pinto and black beans seriously down the list. (June 9 issue of (The Journal of Agricultural and Food Chemistry June 09)

Premenstrual syndrome and calcium

Premenstrual syndrome, PMS is often perceived as a trait of hysterical, hypochondriac women. In fact, it is a serious medical condition with a number of unpleasant symptoms:

• fatigue and trouble sleeping
• upset stomach, bloating, constipation or diarrhea
• headache
• appetite changes or food cravings
• joint or muscle pain
• tension, irritability, mood swings, or crying spells
• anxiety or depression
• trouble concentrating or remembering
• breast swelling and tenderness

As simple a measure as higher intakes of calcium and vitamin D might be helpful in case of PMS. (Archives of Internal Medicine, June 2005).

Most fats seem to be protective against Alzheimer’s disease

Most fats seem to be protective against Alzheimer disease
In 1989-99, an association was found, between dietary fat composition and cognitive performance in later adult years: the higher intake of monounsaturated and polyunsaturated fats and the lower intake of saturated fat — the higher cognitive performance. Another, epidemiologic study conducted in 1997 suggested that high intake of total fat, saturated fat, and dietary cholesterol may increase the risk of dementia.
However, researchers at St Luke’s Medical Center, Chicago, Ill found increased risk of Alzheimer’s disease among people with high intakes of saturated and trans-unsaturated fats and decreased risk with high intakes of polyunsaturated and monounsaturated fats. Consumption of vegetable fat and a high ratio of polyunsaturated to saturated fats were also protective, whereas total fat, animal fat, and dietary cholesterol had no association with Alzheimer disease.
Sources
Brain Res. 1989;505:302-305
Behav Neurosci. 1996;110:451-459
Behav Brain Res. 1999;101:153-161
Am J Epidemiol. 1997;145:33-41.
Arch Neurol. 2003;60:194-200

In 1989-99, an association was found, between dietary fat composition and cognitive performance in later adult years: the higher intake of monounsaturated and polyunsaturated fats and the lower intake of saturated fat — the higher cognitive performance. Another, epidemiologic study conducted in 1997 suggested that high intake of total fat, saturated fat, and dietary cholesterol may increase the risk of dementia.

However, researchers at St Luke’s Medical Center, Chicago, Ill found increased risk of Alzheimer’s disease among people with high intakes of saturated and trans-unsaturated fats and decreased risk with high intakes of polyunsaturated and monounsaturated fats. Consumption of vegetable fat and a high ratio of polyunsaturated to saturated fats were also protective, whereas total fat, animal fat, and dietary cholesterol had no association with Alzheimer disease.

Sources

  1. Brain Res. 1989;505:302-305
  2. Behav Neurosci. 1996;110:451-459
  3. Behav Brain Res. 1999;101:153-161
  4. Am J Epidemiol. 1997;145:33-41.
  5. Arch Neurol. 2003;60:194-200

Flavonoids: what they are, food sources, and brain aging

Flavonoids are water soluble plant pigments that plants produce to assist in photosynthesis and are believed to function as antioxidants.
Major dietary sources of flavonoids include fruits, vegetables, cereals, tea, wine and fruit juices.
The main groups of flavonoids and their food sources are:
flavonols – found in onions, leeks and broccoli;
flavones – found in parsley and celery;
isoflavones – found in soyabeans;
flavanones – found in citrus fruit and tomatoes;
flavanols – abundant in green tea, red wine and cocoa; anthocyanidins’ sources include red wine and red berries.
A recent study has provided strong evidence that dietary flavonoid intake preserved cognitive abilities with aging. Isoflavones from soy had positive effects on cognitive function, because they were able to mimic the actions of estrogens in the brain. Isoflavone supplementation had a favourable effect on verbal memory in post-menopausal women.
Brain-imaging studies in humans have demonstrated that the consumption of flavanol-rich cocoa may enhance blood flow to the brain cortex. Berries, in particular blueberries, are effective at reversing age-related deficits in movements and memory.
Animal studies with tea, grape juice or flavonols such as quercetin have shown that they all are beneficial in reversing the course of neuronal and behavioural ageing. Such beneficial effects have been attributed to antioxidant activities, however, there are growing body of evidence that their mechanisms involve a modulation of neurotransmitter release, a stimulation of neurogenesis and changes in neuronal signaling.
Source: Proceedings of the Nutrition Society (2008), 67: 238-252

Flavonoids are water soluble plant pigments that plants produce to assist in photosynthesis and are believed to function as antioxidants. Major dietary sources of flavonoids include fruits, vegetables, cereals, tea, wine and fruit juices.

The main groups of flavonoids and their food sources are:

  • flavonols – found in onions, leeks and broccoli;
  • flavones – found in parsley and celery;
  • isoflavones – found in soyabeans;
  • flavanones – found in citrus fruit and tomatoes;
  • flavanols – abundant in green tea, red wine and cocoa; anthocyanidins’ sources include red wine and red berries.

A recent study has provided strong evidence that dietary flavonoid intake preserved cognitive abilities with aging. Isoflavones from soy had positive effects on cognitive function, because they were able to mimic the actions of estrogens in the brain. Isoflavone supplementation had a favourable effect on verbal memory in post-menopausal women.

Brain-imaging studies in humans have demonstrated that the consumption of flavanol-rich cocoa may enhance blood flow to the brain cortex. Berries, in particular blueberries, are effective at reversing age-related deficits in movements and memory.

Animal studies with tea, grape juice or flavonols such as quercetin have shown that they all are beneficial in reversing the course of neuronal and behavioural ageing. Such beneficial effects have been attributed to antioxidant activities, however, there are growing body of evidence that their mechanisms involve a modulation of neurotransmitter release, a stimulation of neurogenesis and changes in neuronal signaling.

Source: Proceedings of the Nutrition Society (2008), 67: 238-252

Blueberries, aging, learning, and memory

Phytochemical-rich foods have been shown to be effective at reversing age-related deficits in memory in both animals and humans. Specifically, blueberry were effective in reversing age-related deficits in neuronal signaling and behavioral parameters following 8 weeks of feeding, possibly due to their high flavonoid content. It has been reported that blueberry-supplemented diet may not only retard but also revert declining brain functions due to aging. Young and old rats were trained to memorize objects shown them an hour ago. Old rats receiving 2% of their meals as blueberries performed as young rats while old rats on regular diet failed to memorize the objects at al. In several regions of the brain, old control diet rats had significantly higher levels of so called nuclear factor-kappa B (NF-κB) than young animals on the control diet and old rats eating blueberries (Nutritional Neuroscience, V 7, No 2, 2004, 5-83-9). NF-κB is known for its involvement in vulnerability of neurons to “excitotoxicity” – a toxic biochemical condition occurring during neuronal hyperactivity (Synapse. 2000 Feb;35(2):151-9). Errors in regulation of NF-κB may lead to cancer, inflammation and improper immune development. To resist excitotoxicity, there’s so called Brain-derived neurotrophic factor or BDNF, which function is to help supporting the survival of neurons. Recent data (Free Radical Biology and Medicine, 45, 3, 008, 295-305) on blueberry supplementation may indicate that changes in working memory in aged animals are linked to the effects of flavonoids on BDNF.
It was unclear if phytonutrients from blueberries were able to cross the blood-brain barrier and directly access the brain. Researchers in Barcelona, Spain, investigated this issue. They took old rats and fed them a diet containing 2% blueberries for 2 to 2.5 months, than tested the rats for learning and memory. in the brain areas participating in learning and memory processing and storing – cerebellum, cortex, hippocampus or striatum, 14 antioxidant substances found. The antioxidant content correlated with improvements in learning and memory normally declined in old age rats (and humans). In control rats of same age fed on regular diet, there were no changes in bioche

Phytochemical-rich foods have been shown to be effective at reversing age-related deficits in memory in both animals and humans. Specifically, blueberry were effective in reversing age-related deficits in neuronal signaling and behavioral parameters following 8 weeks of feeding, possibly due to their high flavonoid content. It has been reported that blueberry-supplemented diet may not only retard but also revert declining brain functions due to aging. Young and old rats were trained to memorize objects shown them an hour ago. Old rats receiving 2% of their meals as blueberries performed as young rats while old rats on regular diet failed to memorize the objects at al. In several regions of the brain, old control diet rats had significantly higher levels of so called nuclear factor-kappa B (NF-κB) than young animals on the control diet and old rats eating blueberries (Nutritional Neuroscience, V 7, No 2, 2004, 5-83-9). NF-κB is known for its involvement in vulnerability of neurons to “excitotoxicity” – a toxic biochemical condition occurring during neuronal hyperactivity (Synapse. 2000 Feb;35(2):151-9). Errors in regulation of NF-κB may lead to cancer, inflammation and improper immune development. To resist excitotoxicity, there’s so called Brain-derived neurotrophic factor or BDNF, which function is to help supporting the survival of neurons. Recent data (Free Radical Biology and Medicine, 45, 3, 008, 295-305) on blueberry supplementation may indicate that changes in working memory in aged animals are linked to the effects of flavonoids on BDNF.

It was unclear if phytonutrients from blueberries were able to cross the blood-brain barrier and directly access the brain. Researchers in Barcelona, Spain, investigated this issue. They took old rats and fed them a diet containing 2% blueberries for 2 to 2.5 months, than tested the rats for learning and memory. in the brain areas participating in learning and memory processing and storing – cerebellum, cortex, hippocampus or striatum, 14 antioxidant substances found. The antioxidant content correlated with improvements in learning and memory normally declined in old age rats (and humans). In control rats of same age fed on regular diet, there were no changes in bioche




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